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Compound Detail

CHEMBL1794902

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CCCCCC(=O)O[C@@H]1[C@H](OC(=O)CCCCC)CO[C@@H](OC)[C@@]1(F)CCn1ccc(=O)[nH]c1=O.CCCCCC(=O)O[C@@H]1[C@H](OC(=O)CCCCC)CO[C@H](OC)[C@@]1(F)CCn1ccc(=O)[nH]c1=O

Basic Information

ChEMBL ID CHEMBL1794902
Phase Preclinical
Structure Type MOL
InChI Key ZZJSBBZIDREPFD-GENJETIASA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1001.1
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H74F2N4O16
MW 1001.13

Activity Summary

IC50 1 meas. best 4.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
L1210
CHEMBL386
IC50 4.4 4.4 40000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
L1210 IC50 = 40000.0 nM 4.4 In vitro inhibitory growth activity against L1210 leukemic cells by incubating 5... 2704026

Literature References

PubMed DOI Target Context # Activities
2704026 10.1021/jm00124a013 L1210 1

Data from ChEMBL 36 via Core Engine