Assay Detail
Binding
CHEMBL705075
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Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.10 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318809 | — | — | 1 | 7.52 |
| CHEMBL105139 | — | — | 1 | 6.68 |
| CHEMBL105386 | — | — | 1 | - |
| CHEMBL105587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318809 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL105139 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL105386 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL105587 | — | IC50 | < | 100.0 | nM | - |