Assay Detail
Binding
CHEMBL705077
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Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.92 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49302 | — | — | 1 | 8.46 |
| CHEMBL137248 | — | — | 1 | 7.30 |
| CHEMBL342688 | — | — | 1 | 7.00 |
| CHEMBL136805 | — | — | 1 | 6.85 |
| CHEMBL137168 | — | — | 1 | 6.82 |
| CHEMBL134697 | — | — | 1 | 6.60 |
| CHEMBL335525 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49302 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL137248 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL342688 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL136805 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL137168 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL134697 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL335525 | — | IC50 | = | 4000.0 | nM | 5.40 |