Assay Detail
Binding
CHEMBL705388
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Apparent Ki for rat Lanosterol 14-alpha demethylase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Lanosterol 14-alpha demethylase (CHEMBL4981) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.45 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70396 | — | — | 1 | 7.96 |
| CHEMBL421109 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70396 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL421109 | — | Ki | = | 117.0 | nM | 6.93 |