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Assay Detail

CHEMBL705915

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of radiolabeled spermidine uptake into L1210 cells in vitro.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Antiproliferative properties of polyamine analogues: a structure-activity study.
Bergeron RJ, McManis JS, Liu CZ, Feng Y, Weimar WR, Luchetta GR, Wu Q, Ortiz-Ocasio J, Vinson JR, Kramer D.
J Med Chem (1994) 37 : 3464 -3476
PubMed 7932575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 5.36 6.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81415 1 6.01
CHEMBL274477 1 5.96
CHEMBL83536 1 5.96
CHEMBL77101 DIETHYLHOMOSPERMINE 1.0 1 5.85
CHEMBL18794 BIS(ETHYL)SPERMINE 1 5.80
CHEMBL82888 1 5.77
CHEMBL18111 1 5.64
CHEMBL83086 1 5.52
CHEMBL83336 1 5.40
CHEMBL79699 1 5.25
CHEMBL37795 1 5.22
CHEMBL81361 1 5.11
CHEMBL84121 1 5.10
CHEMBL79550 1 5.09
CHEMBL44083 BIS(ETHYL)NORSPERMINE 1 4.77
CHEMBL421337 1 4.40
CHEMBL310689 1 4.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81415 Ki = 970.0 nM 6.01
CHEMBL274477 Ki = 1100.0 nM 5.96
CHEMBL83536 Ki = 1100.0 nM 5.96
CHEMBL77101 DIETHYLHOMOSPERMINE Ki = 1400.0 nM 5.85
CHEMBL18794 BIS(ETHYL)SPERMINE Ki = 1600.0 nM 5.80
CHEMBL82888 Ki = 1700.0 nM 5.77
CHEMBL18111 Ki = 2300.0 nM 5.64
CHEMBL83086 Ki = 3000.0 nM 5.52
CHEMBL83336 Ki = 4000.0 nM 5.40
CHEMBL79699 Ki = 5600.0 nM 5.25
CHEMBL37795 Ki = 6000.0 nM 5.22
CHEMBL81361 Ki = 7700.0 nM 5.11
CHEMBL84121 Ki = 8000.0 nM 5.10
CHEMBL79550 Ki = 8100.0 nM 5.09
CHEMBL44083 BIS(ETHYL)NORSPERMINE Ki = 17000.0 nM 4.77
CHEMBL421337 Ki = 40000.0 nM 4.40
CHEMBL310689 Ki = 56000.0 nM 4.25