Compound Detail
CHEMBL274477
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Basic Information
| ChEMBL ID | CHEMBL274477 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHMQCHCWNFTZMN-UHFFFAOYSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
230.4
MW (Da)
0.16
ALogP
4
HBA
4
HBD
48.1
PSA (Ų)
0.34
QED
0
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.12
Ki 2 meas. best 5.96
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| L1210 | IC50 | = | 750.0 | nM | 6.12 | In vitro inhibition of L1210 growth after 96 hours. | 7932575 |
| L1210 | IC50 | = | 750.0 | nM | 6.12 | Tested for inhibition of L1210 cell growth by the compound after 96 hr | 3373487 |
| L1210 | Ki | = | 1100.0 | nM | 5.96 | Inhibition of radiolabeled spermidine uptake into L1210 cells in vitro. | 7932575 |
| L1210 | Ki | = | 1100.0 | nM | 5.96 | In vitro inhibition of uptake [3H]-spermidine in L1210 (murine leukemia) cells. | 8691443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7932575 | 10.1021/jm00047a004 | L1210 | 11 |
| 3373487 | 10.1021/jm00401a019 | L1210 | 2 |
| 7853334 | 10.1021/jm00003a004 | Rattus norvegicus | 2 |
| 7932575 | 10.1021/jm00047a004 | Ornithine decarboxylase | 1 |
| 7932575 | 10.1021/jm00047a004 | S-adenosylmethionine decarboxylase proenzyme 1 | 1 |
| 7932575 | 10.1021/jm00047a004 | Spermidine/spermine N(1)-acetyltransferase (SAT) | 1 |
| 8691443 | 10.1021/jm950827h | L1210 | 1 |
Data from ChEMBL 36 via Core Engine