Assay Detail
Functional
CHEMBL705960
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Concentration required for 50% reduction in KB cell number after 3-day incubation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.23 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.70 |
| CHEMBL281692 | — | — | 1 | 6.62 |
| CHEMBL286509 | — | — | 1 | 6.35 |
| CHEMBL283631 | — | — | 1 | 6.31 |
| CHEMBL32519 | — | — | 1 | 6.17 |
| CHEMBL169066 | — | — | 1 | 5.24 |
| CHEMBL3085153 | — | — | 1 | - |
| CHEMBL168532 | — | — | 1 | - |
| CHEMBL170852 | — | — | 1 | - |
| CHEMBL352613 | — | — | 1 | - |
| CHEMBL168588 | — | — | 1 | - |
| CHEMBL420565 | — | — | 1 | - |
| CHEMBL353229 | — | — | 1 | - |
| CHEMBL354213 | — | — | 1 | - |
| CHEMBL168995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL281692 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL286509 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL283631 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL32519 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL169066 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3085153 | — | IC50 | > | 6400.0 | nM | - |
| CHEMBL168532 | — | IC50 | > | 6800.0 | nM | - |
| CHEMBL170852 | — | IC50 | > | 7200.0 | nM | - |
| CHEMBL352613 | — | IC50 | > | 7000.0 | nM | - |
| CHEMBL168588 | — | IC50 | > | 7200.0 | nM | - |
| CHEMBL420565 | — | IC50 | > | 22300.0 | nM | - |
| CHEMBL353229 | — | IC50 | > | 7500.0 | nM | - |
| CHEMBL354213 | — | IC50 | > | 7200.0 | nM | - |
| CHEMBL168995 | — | IC50 | > | 7300.0 | nM | - |