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Assay Detail

CHEMBL705972

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Functional
In vitro cell survival assay on cancer KB cell lines
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

New synthesis of benzo-delta-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of delta-carbolines, benzo-delta-carbolines, and cryptolepines.
Arzel E, Rocca P, Grellier P, Labaeïd M, Frappier F, Guéritte F, Gaspard C, Marsais F, Godard A, Quéguiner G.
J Med Chem (2001) 44 : 949 -960
PubMed 11300877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.43 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL173192 1 6.38
CHEMBL172138 1 6.28
CHEMBL176533 1 6.24
CHEMBL369675 1 6.16
CHEMBL368186 1 6.12
CHEMBL119096 CRYPTOLEPINE 1 5.82
CHEMBL174708 1 5.82
CHEMBL92129 CRYPTOLEPINE HYDROCHLORIDE 1 5.76
CHEMBL172137 1 5.19
CHEMBL172918 1 5.19
CHEMBL367500 1 5.03
CHEMBL172479 1 4.40
CHEMBL173684 1 4.40
CHEMBL224248 QUINDOLINE 1 4.35
CHEMBL368652 1 4.24
CHEMBL367464 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL173192 IC50 = 420.0 nM 6.38
CHEMBL172138 IC50 = 530.0 nM 6.28
CHEMBL176533 IC50 = 570.0 nM 6.24
CHEMBL369675 IC50 = 700.0 nM 6.16
CHEMBL368186 IC50 = 750.0 nM 6.12
CHEMBL119096 CRYPTOLEPINE IC50 = 1500.0 nM 5.82
CHEMBL174708 IC50 = 1500.0 nM 5.82
CHEMBL92129 CRYPTOLEPINE HYDROCHLORIDE IC50 = 1750.0 nM 5.76
CHEMBL172137 IC50 = 6500.0 nM 5.19
CHEMBL172918 IC50 = 6400.0 nM 5.19
CHEMBL367500 IC50 = 9250.0 nM 5.03
CHEMBL172479 IC50 = 40000.0 nM 4.40
CHEMBL173684 IC50 = 40000.0 nM 4.40
CHEMBL224248 QUINDOLINE IC50 = 45000.0 nM 4.35
CHEMBL368652 IC50 = 57000.0 nM 4.24
CHEMBL367464 IC50 > 100000.0 nM -