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Assay Detail

CHEMBL705977

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Functional
Inhibit growth of KB cells by 50%
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
Yamato M, Ando J, Sakaki K, Hashigaki K, Wataya Y, Tsukagoshi S, Tashiro T, Tsuruo T.
J Med Chem (1992) 35 : 267 -273
PubMed 1732542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.45 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL447827 1 5.96
CHEMBL330519 1 5.82
CHEMBL327803 1 5.80
CHEMBL330347 1 5.80
CHEMBL275865 1 5.80
CHEMBL48310 HINOKITIOL 1 5.46
CHEMBL90658 1 5.37
CHEMBL93183 1 5.21
CHEMBL90517 1 5.10
CHEMBL91395 1 5.02
CHEMBL327550 1 4.56
CHEMBL310555 OXYQUINOLINE -1.0 1 -
CHEMBL56846 1 -
CHEMBL21845 1 -
CHEMBL90474 1 -
CHEMBL267233 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL447827 IC50 = 1100.0 nM 5.96
CHEMBL330519 IC50 = 1500.0 nM 5.82
CHEMBL327803 IC50 = 1600.0 nM 5.80
CHEMBL330347 IC50 = 1600.0 nM 5.80
CHEMBL275865 IC50 = 1600.0 nM 5.80
CHEMBL48310 HINOKITIOL IC50 = 3500.0 nM 5.46
CHEMBL90658 IC50 = 4300.0 nM 5.37
CHEMBL93183 IC50 = 6200.0 nM 5.21
CHEMBL90517 IC50 = 8000.0 nM 5.10
CHEMBL91395 IC50 = 9500.0 nM 5.02
CHEMBL327550 IC50 = 27300.0 nM 4.56
CHEMBL310555 OXYQUINOLINE IC50 < 2100.0 nM -
CHEMBL56846 IC50 < 700.0 nM -
CHEMBL21845 IC50 = 114000.0 nM -
CHEMBL90474 IC50 < 900.0 nM -
CHEMBL267233 IC50 > 249000.0 nM -