Assay Detail
Functional
CHEMBL705978
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Inhibition of EGF-stimulated proliferation of KB cells in culture
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Epidermal growth factor receptor tyrosine kinase: Structure-activity relationships and antitumour activity of novel quinazolines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.03 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301018 | — | — | 1 | 7.10 |
| CHEMBL419137 | — | — | 1 | 6.85 |
| CHEMBL91484 | — | — | 1 | 6.51 |
| CHEMBL329867 | — | — | 1 | 6.44 |
| CHEMBL420059 | — | — | 1 | 6.24 |
| CHEMBL422066 | — | — | 1 | 6.11 |
| CHEMBL91428 | — | — | 1 | 6.09 |
| CHEMBL93173 | — | — | 1 | 5.80 |
| CHEMBL94019 | — | — | 1 | 5.76 |
| CHEMBL330323 | — | — | 1 | 5.75 |
| CHEMBL92006 | — | — | 1 | 5.41 |
| CHEMBL328277 | — | — | 1 | 5.39 |
| CHEMBL90540 | — | — | 1 | 4.94 |
| CHEMBL90541 | — | — | 1 | - |
| CHEMBL93423 | — | — | 1 | - |
| CHEMBL330668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301018 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL419137 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL91484 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL329867 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL420059 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL422066 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL91428 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL93173 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL94019 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL330323 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL92006 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL328277 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL90540 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL90541 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL93423 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL330668 | — | IC50 | > | 25000.0 | nM | - |