Assay Detail
Functional
CHEMBL706010
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Compound was tested in vitro against L1210 leukemia cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity, and preliminary toxicity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.63 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156917 | — | — | 1 | 9.54 |
| CHEMBL346583 | — | — | 1 | 9.36 |
| CHEMBL346043 | — | — | 1 | 9.19 |
| CHEMBL440005 | — | — | 1 | 9.07 |
| CHEMBL351122 | — | — | 1 | 9.00 |
| CHEMBL538915 | — | — | 1 | 8.92 |
| CHEMBL288612 | — | — | 1 | 8.92 |
| CHEMBL38957 | — | — | 1 | 8.60 |
| CHEMBL347890 | — | — | 1 | 8.24 |
| CHEMBL156141 | — | — | 1 | 7.36 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156917 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL346583 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL346043 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL440005 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL351122 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL538915 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL288612 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL38957 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL347890 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL156141 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 179.0 | nM | 6.75 |