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Compound Detail

CHEMBL538915

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CC(=O)Nc1ccc2[nH]c(C(=O)Nc3ccc4[nH]c(C(=O)N5C[C@@H](CCl)c6c5cc(O)c5ccccc65)cc4c3)cc2c1

Basic Information

ChEMBL ID CHEMBL538915
Phase Preclinical
Structure Type MOL
InChI Key BIIZHPQOVMNVIQ-HXUWFJFHSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

592.1
MW (Da)
6.70
ALogP
4
HBA
5
HBD
130.3
PSA (Ų)
0.14
QED
2
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H26ClN5O4
MW 592.06
Aromatic Rings 6
Heavy Atoms 43
NP-Likeness -0.61

Activity Summary

IC50 1 meas. best 8.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
L1210
CHEMBL386
IC50 8.92 8.92 1.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
L1210 IC50 = 1.2 nM 8.92 Compound was tested in vitro against L1210 leukemia cells 12570384

Literature References

PubMed DOI Target Context # Activities
12570384 10.1021/jm0203433 Mus musculus 11
12570384 10.1021/jm0203433 L1210 1

Data from ChEMBL 36 via Core Engine