Assay Detail
Binding
CHEMBL706152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H](+)-PN200-110 binding to calcium channels of rat cerebral cortex membrane.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and pharmacological characterization of methyl(omega-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate iodide, calcium channel antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.06 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350227 | — | — | 1 | 7.61 |
| CHEMBL609701 | — | — | 1 | 7.43 |
| CHEMBL2092919 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350227 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL609701 | — | Ki | = | 37.2 | nM | 7.43 |
| CHEMBL2092919 | — | Ki | = | 717.8 | nM | 6.14 |