Assay Detail
Binding
CHEMBL706154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H](+)-PN200-110 binding to calcium channels of rat heart membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL3762) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and pharmacological characterization of methyl(omega-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate iodide, calcium channel antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.13 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350227 | — | — | 1 | 8.10 |
| CHEMBL609701 | — | — | 1 | 7.00 |
| CHEMBL2092919 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350227 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL609701 | — | Ki | = | 99.2 | nM | 7.00 |
| CHEMBL2092919 | — | Ki | = | 497.0 | nM | 6.30 |