Assay Detail
Binding
CHEMBL706199
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Ability to inhibit skeletal muscle LDH (LDH-M4)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.66 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160432 | — | — | 1 | 4.75 |
| CHEMBL434275 | — | — | 1 | 4.56 |
| CHEMBL139402 | — | — | 1 | - |
| CHEMBL138027 | — | — | 1 | - |
| CHEMBL141025 | — | — | 1 | - |
| CHEMBL343799 | — | — | 1 | - |
| CHEMBL139244 | — | — | 1 | - |
| CHEMBL1161215 | — | — | 1 | - |
| CHEMBL138298 | — | — | 1 | - |
| CHEMBL344461 | — | — | 1 | - |
| CHEMBL139078 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160432 | — | IC50 | = | 17782.79 | nM | 4.75 |
| CHEMBL434275 | — | IC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL139402 | — | IC50 | = | 575439.94 | nM | - |
| CHEMBL138027 | — | IC50 | = | 1122018.45 | nM | - |
| CHEMBL141025 | — | IC50 | = | 562341.33 | nM | - |
| CHEMBL343799 | — | IC50 | = | 407380.28 | nM | - |
| CHEMBL139244 | — | IC50 | = | 954992.59 | nM | - |
| CHEMBL1161215 | — | IC50 | = | 870963.59 | nM | - |
| CHEMBL138298 | — | IC50 | = | 316227.77 | nM | - |
| CHEMBL344461 | — | IC50 | = | 1819700.86 | nM | - |
| CHEMBL139078 | — | IC50 | = | 1230268.77 | nM | - |