Assay Detail
Functional
CHEMBL706282
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In vitro concentration required to kill 50% of LNCaP human prostate cancer cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.56 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142678 | — | — | 1 | 7.00 |
| CHEMBL357171 | — | — | 1 | 6.52 |
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.30 |
| CHEMBL413081 | — | — | 1 | 6.00 |
| CHEMBL266634 | — | — | 1 | 5.80 |
| CHEMBL383912 | — | — | 1 | 5.40 |
| CHEMBL412869 | — | — | 1 | 5.03 |
| CHEMBL384108 | — | — | 1 | 4.80 |
| CHEMBL439254 | — | — | 1 | 4.40 |
| CHEMBL265312 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142678 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL357171 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL378544 | VINBLASTINE SULFATE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL413081 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL266634 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL383912 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL412869 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL384108 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL439254 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL265312 | — | EC50 | = | 48000.0 | nM | 4.32 |