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Assay Detail

CHEMBL706507

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity was evaluated against LS174T-stCPG2(Q)3-expressing cell clone
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
J Med Chem (1998) 41 : 5297 -5309
PubMed 9857097 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.96 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL275497 1 6.47
CHEMBL356902 1 6.38
CHEMBL46003 1 6.34
CHEMBL435088 1 6.32
CHEMBL46726 1 6.21
CHEMBL12995 1 5.42
CHEMBL12644 1 4.56
CHEMBL345057 1 -
CHEMBL148999 1 -
CHEMBL151957 1 -
CHEMBL148945 1 -
CHEMBL357546 1 -
CHEMBL346426 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL275497 IC50 = 340.0 nM 6.47
CHEMBL356902 IC50 = 420.0 nM 6.38
CHEMBL46003 IC50 = 460.0 nM 6.34
CHEMBL435088 IC50 = 480.0 nM 6.32
CHEMBL46726 IC50 = 620.0 nM 6.21
CHEMBL12995 IC50 = 3780.0 nM 5.42
CHEMBL12644 IC50 = 27780.0 nM 4.56
CHEMBL345057 IC50 = 322900.0 nM -
CHEMBL148999 IC50 = 183500.0 nM -
CHEMBL151957 IC50 = 256700.0 nM -
CHEMBL148945 IC50 = 121300.0 nM -
CHEMBL357546 IC50 = 264100.0 nM -
CHEMBL346426 IC50 = 128000.0 nM -