Assay Detail
Binding
CHEMBL706534
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In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacologic activity of hydroxyacetophenone-substituted benzophenone/xanthone leukotriene B4 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.76 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 8.72 |
| CHEMBL292768 | — | — | 1 | 8.40 |
| CHEMBL49210 | — | — | 1 | 8.21 |
| CHEMBL49302 | — | — | 1 | 7.89 |
| CHEMBL60881 | — | — | 1 | 7.34 |
| CHEMBL15766 | LY-255283 | — | 1 | 7.07 |
| CHEMBL58534 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL292768 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL49210 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL49302 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL60881 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL15766 | LY-255283 | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL58534 | — | IC50 | = | 190.0 | nM | 6.72 |