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Assay Detail

CHEMBL706535

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Leukotriene B4 receptor 1 (CHEMBL3911)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B4 receptor antagonists
Greenspan PD, Main AJ, Bhagwat SS, Barsky LI, Doti RA, Engle AR, Frey LM, Zhou H, Lipson KE, Chin MH, Jackson RH, Uziel-Fusi S
Bioorg Med Chem Lett (1997) 7 : 949 -954
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.37 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL175073 1 7.80
CHEMBL424779 1 7.78
CHEMBL367943 1 7.17
CHEMBL174638 1 6.72
CHEMBL172974 1 6.56
CHEMBL426773 1 6.11
CHEMBL176974 1 6.08
CHEMBL176903 1 6.04
CHEMBL175128 1 6.03
CHEMBL367291 1 5.93
CHEMBL172201 1 5.93
CHEMBL176747 1 5.91
CHEMBL172091 1 5.82
CHEMBL176748 1 5.34
CHEMBL171853 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL175073 IC50 = 15.9 nM 7.80
CHEMBL424779 IC50 = 16.7 nM 7.78
CHEMBL367943 IC50 = 68.2 nM 7.17
CHEMBL174638 IC50 = 190.0 nM 6.72
CHEMBL172974 IC50 = 276.0 nM 6.56
CHEMBL426773 IC50 = 784.0 nM 6.11
CHEMBL176974 IC50 = 830.0 nM 6.08
CHEMBL176903 IC50 = 908.0 nM 6.04
CHEMBL175128 IC50 = 932.0 nM 6.03
CHEMBL367291 IC50 = 1180.0 nM 5.93
CHEMBL172201 IC50 = 1180.0 nM 5.93
CHEMBL176747 IC50 = 1220.0 nM 5.91
CHEMBL172091 IC50 = 1510.0 nM 5.82
CHEMBL176748 IC50 = 4570.0 nM 5.34
CHEMBL171853 IC50 > 10000.0 nM -