Assay Detail
Binding
CHEMBL706536
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Inhibition against LTB4 receptor in human neutrophil
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.35 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15299 | — | — | 1 | 7.64 |
| CHEMBL15295 | — | — | 1 | 7.44 |
| CHEMBL15559 | — | — | 1 | 7.40 |
| CHEMBL15817 | — | — | 1 | 7.38 |
| CHEMBL15648 | — | — | 1 | 7.17 |
| CHEMBL15766 | LY-255283 | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15299 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL15295 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL15559 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL15817 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL15648 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL15766 | LY-255283 | IC50 | = | 85.1 | nM | 7.07 |