Assay Detail
Binding
CHEMBL706545
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Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.42 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284228 | — | — | 1 | 4.60 |
| CHEMBL140459 | — | — | 1 | 4.24 |
| CHEMBL27803 | — | — | 1 | - |
| CHEMBL27690 | — | — | 1 | - |
| CHEMBL2114365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284228 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL140459 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL27803 | — | Ki | = | 350000.0 | nM | - |
| CHEMBL27690 | — | Ki | = | 1100000.0 | nM | - |
| CHEMBL2114365 | — | Ki | = | 240000.0 | nM | - |