Assay Detail
Binding
CHEMBL706757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.40 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168854 | — | — | 1 | 6.62 |
| CHEMBL172457 | — | — | 1 | 6.48 |
| CHEMBL169639 | — | — | 1 | 5.72 |
| CHEMBL171666 | — | — | 1 | 5.48 |
| CHEMBL352814 | — | — | 1 | 5.28 |
| CHEMBL414462 | — | — | 1 | 4.80 |
| CHEMBL169743 | — | — | 1 | 4.42 |
| CHEMBL282524 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168854 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL172457 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL169639 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL171666 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL352814 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL414462 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL169743 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL282524 | — | Ki | = | 38000.0 | nM | 4.42 |