Assay Detail
Binding
CHEMBL706760
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Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.47 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292782 | — | — | 1 | 9.33 |
| CHEMBL340460 | — | — | 1 | 9.24 |
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 8.72 |
| CHEMBL88337 | — | — | 1 | 8.40 |
| CHEMBL129272 | — | — | 1 | 7.66 |
| CHEMBL129463 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292782 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL340460 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL65061 | LEUKOTRIENE_B4 | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL88337 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL129272 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL129463 | — | Ki | = | 36.0 | nM | 7.44 |