Assay Detail
Functional
CHEMBL706831
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Tested for 50% effective concentration based on the inhibition of HIV-I induced cytopathic effect in MT-4 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Utilization of wieland furoxan synthesis for preparation of 4-aryl-1,2,5-oxadiazole-3-yl carbamate derivatives having potent anti-HIV activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.48 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL60314 | — | — | 1 | 7.89 |
| CHEMBL61564 | — | — | 1 | 6.92 |
| CHEMBL61423 | — | — | 1 | 5.70 |
| CHEMBL294325 | — | — | 1 | 5.25 |
| CHEMBL60566 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL60314 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL61564 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL61423 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL294325 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL60566 | — | EC50 | = | 20000.0 | nM | 4.70 |