Assay Detail
Functional
CHEMBL706835
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Antiviral activity against PI resistant virus D545701 was determined in MT-4 cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.07 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433973 | — | — | 1 | 8.04 |
| CHEMBL368496 | — | — | 1 | 7.40 |
| CHEMBL171947 | — | — | 1 | 7.19 |
| CHEMBL174779 | — | — | 1 | 7.18 |
| CHEMBL173569 | — | — | 1 | 7.00 |
| CHEMBL353288 | — | — | 1 | 6.92 |
| CHEMBL367454 | — | — | 1 | 6.82 |
| CHEMBL355306 | — | — | 1 | 6.70 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 6.36 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | - |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433973 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL368496 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL171947 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL174779 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL173569 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL353288 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL367454 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL355306 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL584 | NELFINAVIR | IC50 | > | 1000.0 | nM | - |
| CHEMBL116 | AMPRENAVIR | IC50 | > | 1000.0 | nM | - |