Assay Detail
Functional
CHEMBL706845
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Potency against non nucleoside reverse transcriptor was determined in MT-4 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Threshold interaction energy of NRTI's (2'-deoxy 3'-substituted nucleosidic analogs of reverse transcriptase inhibitors) to undergo competitive inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.44 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.40 |
| CHEMBL38679 | — | — | 1 | 7.30 |
| CHEMBL299714 | — | — | 1 | 6.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.22 |
| CHEMBL543611 | TROVIRDINE HYDROCHLORIDE | — | 1 | 6.10 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.80 |
| CHEMBL226345 | ADENINE | 3.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL38679 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL299714 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL543611 | TROVIRDINE HYDROCHLORIDE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL226345 | ADENINE | IC50 | = | 12000.0 | nM | 4.92 |