Assay Detail
Functional
CHEMBL706893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition against human MCF-7 cell lines
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.89 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440896 | — | — | 1 | 6.80 |
| CHEMBL430890 | — | — | 1 | 6.42 |
| CHEMBL331583 | — | — | 1 | 6.38 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.27 |
| CHEMBL116696 | — | — | 1 | 6.21 |
| CHEMBL117966 | — | — | 1 | 6.19 |
| CHEMBL323906 | — | — | 1 | 6.17 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.13 |
| CHEMBL117076 | — | — | 1 | 5.83 |
| CHEMBL117195 | — | — | 1 | 5.83 |
| CHEMBL113815 | — | — | 1 | 5.79 |
| CHEMBL117536 | — | — | 1 | 5.53 |
| CHEMBL118079 | — | — | 1 | 5.04 |
| CHEMBL116569 | — | — | 1 | 4.95 |
| CHEMBL114935 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440896 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL430890 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL331583 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL116696 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL117966 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL323906 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL117076 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL117195 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL113815 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL117536 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL118079 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL116569 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL114935 | — | IC50 | = | 16390.0 | nM | 4.79 |