Assay Detail
Binding
CHEMBL706927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.73 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343934 | — | — | 1 | 9.77 |
| CHEMBL140381 | — | — | 1 | 9.46 |
| CHEMBL341603 | — | — | 1 | 9.37 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.37 |
| CHEMBL341547 | — | — | 1 | 9.30 |
| CHEMBL342705 | — | — | 1 | 9.20 |
| CHEMBL143597 | — | — | 1 | 9.15 |
| CHEMBL348229 | — | — | 1 | 9.12 |
| CHEMBL342784 | — | — | 1 | 8.92 |
| CHEMBL141405 | — | — | 1 | 8.87 |
| CHEMBL140761 | — | — | 1 | 8.77 |
| CHEMBL141640 | — | — | 1 | 8.74 |
| CHEMBL344180 | — | — | 1 | 8.74 |
| CHEMBL139757 | — | — | 1 | 8.68 |
| CHEMBL141234 | — | — | 1 | 8.47 |
| CHEMBL143515 | — | — | 1 | 8.35 |
| CHEMBL344169 | — | — | 1 | 8.33 |
| CHEMBL140058 | — | — | 1 | 8.32 |
| CHEMBL141841 | — | — | 1 | 7.61 |
| CHEMBL143115 | — | — | 1 | 7.43 |
| CHEMBL345093 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343934 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL140381 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL341603 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL341547 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL342705 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL143597 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL348229 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL342784 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL141405 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL140761 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL141640 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL344180 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL139757 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL141234 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL143515 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL344169 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL140058 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL141841 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL143115 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL345093 | — | IC50 | = | 50.4 | nM | 7.30 |