Assay Detail
Binding
CHEMBL706928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.63 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344180 | — | — | 1 | 9.72 |
| CHEMBL343934 | — | — | 1 | 9.72 |
| CHEMBL139757 | — | — | 1 | 9.68 |
| CHEMBL341603 | — | — | 1 | 9.47 |
| CHEMBL143515 | — | — | 1 | 9.30 |
| CHEMBL143597 | — | — | 1 | 9.30 |
| CHEMBL342705 | — | — | 1 | 9.29 |
| CHEMBL141640 | — | — | 1 | 9.24 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.19 |
| CHEMBL141405 | — | — | 1 | 9.14 |
| CHEMBL140058 | — | — | 1 | 9.13 |
| CHEMBL143326 | — | — | 1 | 9.10 |
| CHEMBL141234 | — | — | 1 | 9.10 |
| CHEMBL140381 | — | — | 1 | 9.06 |
| CHEMBL341547 | — | — | 1 | 9.05 |
| CHEMBL141841 | — | — | 1 | 9.05 |
| CHEMBL140761 | — | — | 1 | 8.92 |
| CHEMBL341814 | — | — | 1 | 8.92 |
| CHEMBL342784 | — | — | 1 | 8.85 |
| CHEMBL341657 | — | — | 1 | 8.62 |
| CHEMBL358142 | — | — | 1 | 8.62 |
| CHEMBL348229 | — | — | 1 | 8.59 |
| CHEMBL345093 | — | — | 1 | 8.57 |
| CHEMBL344169 | — | — | 1 | 8.31 |
| CHEMBL140644 | — | — | 1 | 7.93 |
| CHEMBL139560 | — | — | 1 | 7.90 |
| CHEMBL424108 | — | — | 1 | 7.64 |
| CHEMBL342588 | — | — | 1 | 7.60 |
| CHEMBL143115 | — | — | 1 | 7.60 |
| CHEMBL434445 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344180 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL343934 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL139757 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL341603 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL143515 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL143597 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL342705 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL141640 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL141405 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL140058 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL143326 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL141234 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL140381 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL141841 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL341547 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL140761 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL341814 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL342784 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL341657 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL358142 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL348229 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL345093 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL344169 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL140644 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL139560 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL424108 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL342588 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL143115 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL434445 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL335332 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL141300 | — | IC50 | = | 421.0 | nM | 6.38 |