Assay Detail
Binding
CHEMBL706932
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Inhibition of binding of [3H]LTD4 to guinea pig lung membrane supplemented with 0.05% human serum albumin(HSA)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.04 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313187 | — | — | 1 | 9.70 |
| CHEMBL313195 | — | — | 1 | 9.62 |
| CHEMBL314237 | — | — | 1 | 9.59 |
| CHEMBL414885 | — | — | 1 | 9.54 |
| CHEMBL315973 | — | — | 1 | 9.47 |
| CHEMBL87337 | — | — | 1 | 9.47 |
| CHEMBL86302 | — | — | 1 | 9.43 |
| CHEMBL86063 | — | — | 1 | 9.32 |
| CHEMBL314340 | — | — | 1 | 9.24 |
| CHEMBL87696 | — | — | 1 | 9.19 |
| CHEMBL87528 | — | — | 1 | 9.06 |
| CHEMBL82790 | — | — | 1 | 8.99 |
| CHEMBL313177 | — | — | 1 | 8.92 |
| CHEMBL84841 | — | — | 1 | 8.85 |
| CHEMBL84707 | — | — | 1 | 8.80 |
| CHEMBL85572 | — | — | 1 | 8.71 |
| CHEMBL85633 | — | — | 1 | 8.66 |
| CHEMBL316170 | — | — | 1 | 8.49 |
| CHEMBL83233 | — | — | 1 | 8.04 |
| CHEMBL86264 | — | — | 1 | 7.69 |
| CHEMBL313544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313187 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL313195 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL314237 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL414885 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL315973 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL87337 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL86302 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL86063 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL314340 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL87696 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL87528 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL82790 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL313177 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL84841 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL84707 | — | IC50 | = | 1.58 | nM | 8.80 |
| CHEMBL85572 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL85633 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL316170 | — | IC50 | = | 3.21 | nM | 8.49 |
| CHEMBL83233 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL86264 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL313544 | — | IC50 | > | 150.0 | nM | - |