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Assay Detail

CHEMBL707030

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition against human LCLC-103H cell lines
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LCLC-103H
Confidence 1 — Organism
Curated By Expert

Target

LCLC-103H cell line (CHEMBL614066)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Saczewski F, Reszka P, Gdaniec M, Grünert R, Bednarski PJ.
J Med Chem (2004) 47 : 3438 -3449
PubMed 15189040 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.05 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL440896 1 6.80
CHEMBL116696 1 6.54
CHEMBL430890 1 6.48
CHEMBL117076 1 6.46
CHEMBL113922 1 6.25
CHEMBL117966 1 6.19
CHEMBL323906 1 6.17
CHEMBL113815 1 6.16
CHEMBL331583 1 6.11
CHEMBL114935 1 5.95
CHEMBL334049 1 5.85
CHEMBL118079 1 5.80
CHEMBL11359 CISPLATIN 4.0 1 5.79
CHEMBL117195 1 5.78
CHEMBL331840 1 5.71
CHEMBL118009 1 5.68
CHEMBL116569 1 5.60
CHEMBL117536 1 5.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL440896 IC50 = 160.0 nM 6.80
CHEMBL116696 IC50 = 290.0 nM 6.54
CHEMBL430890 IC50 = 330.0 nM 6.48
CHEMBL117076 IC50 = 350.0 nM 6.46
CHEMBL113922 IC50 = 560.0 nM 6.25
CHEMBL117966 IC50 = 650.0 nM 6.19
CHEMBL323906 IC50 = 680.0 nM 6.17
CHEMBL113815 IC50 = 700.0 nM 6.16
CHEMBL331583 IC50 = 780.0 nM 6.11
CHEMBL114935 IC50 = 1130.0 nM 5.95
CHEMBL334049 IC50 = 1420.0 nM 5.85
CHEMBL118079 IC50 = 1600.0 nM 5.80
CHEMBL11359 CISPLATIN IC50 = 1630.0 nM 5.79
CHEMBL117195 IC50 = 1650.0 nM 5.78
CHEMBL331840 IC50 = 1970.0 nM 5.71
CHEMBL118009 IC50 = 2110.0 nM 5.68
CHEMBL116569 IC50 = 2500.0 nM 5.60
CHEMBL117536 IC50 = 2970.0 nM 5.53