Assay Detail
Functional
CHEMBL707058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against lysophosphatidic acid receptor 1 using [35S]GTP-gamma-S as radioligand tested in vitro
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.79 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117021 | LYSOPHOSPHATIDIC ACID | — | 1 | 7.77 |
| CHEMBL117798 | — | — | 1 | 7.40 |
| CHEMBL117754 | — | — | 1 | 6.71 |
| CHEMBL117529 | — | — | 1 | 6.66 |
| CHEMBL325970 | — | — | 1 | 6.50 |
| CHEMBL331661 | — | — | 1 | 5.71 |
| CHEMBL117663 | — | — | 1 | - |
| CHEMBL117860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117021 | LYSOPHOSPHATIDIC ACID | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL117798 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL117754 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL117529 | — | EC50 | = | 221.0 | nM | 6.66 |
| CHEMBL325970 | — | EC50 | = | 318.0 | nM | 6.50 |
| CHEMBL331661 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL117663 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL117860 | — | EC50 | > | 5000.0 | nM | - |