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Assay Detail

CHEMBL707113

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of L1210 (murine leukemia) cell growth.
18
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and antitumor activity of cis-dichloroplatinum (II)-N-aminated nucleoside complexes.
Maeda M, Abiko N, Uchida H, Sasaki T.
J Med Chem (1984) 27 : 444 -449
PubMed 6538600 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.64 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267099 TUBERCIDIN 2 7.17
CHEMBL11359 CISPLATIN 4.0 2 6.20
CHEMBL2092980 Platinum complex 2 5.44
CHEMBL607792 3-aminotubercidin-dichloroplatinum (II) 2 5.05
CHEMBL3143168 2 4.36
CHEMBL2092804 2 -
CHEMBL2092981 1 -
CHEMBL3144267 2 -
CHEMBL2092802 3-aminocytidine-dichloroplatinum (II) 2 -
CHEMBL1163092 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267099 TUBERCIDIN IC50 = 67.7 nM 7.17
CHEMBL11359 CISPLATIN IC50 = 633.0 nM 6.20
CHEMBL2092980 Platinum complex IC50 = 3630.0 nM 5.44
CHEMBL607792 3-aminotubercidin-dichloroplatinum (II) IC50 = 8960.0 nM 5.05
CHEMBL3143168 IC50 = 43300.0 nM 4.36
CHEMBL2092804 IC50 = 1360000.0 nM -
CHEMBL2092981 IC50 = 45.0 ug.mL-1 -
CHEMBL2092980 Platinum complex IC50 = 1.9 ug.mL-1 -
CHEMBL3144267 IC50 = 2000.0 ug.mL-1 -
CHEMBL3144267 IC50 = 7180000.0 nM -
CHEMBL2092802 3-aminocytidine-dichloroplatinum (II) IC50 = 64.0 ug.mL-1 -
CHEMBL2092802 3-aminocytidine-dichloroplatinum (II) IC50 = 122000.0 nM -
CHEMBL2092804 IC50 = 400.0 ug.mL-1 -
CHEMBL1163092 IC50 = 2.7 ug.mL-1 -
CHEMBL3143168 IC50 = 22.0 ug.mL-1 -
CHEMBL267099 TUBERCIDIN IC50 = 0.018 ug.mL-1 -
CHEMBL11359 CISPLATIN IC50 = 0.19 ug.mL-1 -
CHEMBL607792 3-aminotubercidin-dichloroplatinum (II) IC50 = 4.9 ug.mL-1 -