Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL707299

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro for its inhibitory activity against L1210 murine leukemia cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates and related derivatives: a new class of potential antineoplastic and antifilarial agents.
Ram S, Wise DS, Wotring LL, McCall JW, Townsend LB.
J Med Chem (1992) 35 : 539 -547
PubMed 1738146 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.60 7.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9514 NOCODAZOLE 2.0 1 7.42
CHEMBL149748 1 6.16
CHEMBL155162 1 6.14
CHEMBL149572 1 6.13
CHEMBL151945 1 6.12
CHEMBL155223 1 5.70
CHEMBL150758 1 5.66
CHEMBL433544 1 5.55
CHEMBL346848 1 5.30
CHEMBL153091 1 5.16
CHEMBL150902 1 5.13
CHEMBL358941 1 5.09
CHEMBL153699 1 5.07
CHEMBL153323 1 5.00
CHEMBL150659 1 5.00
CHEMBL153338 1 5.00
CHEMBL358937 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9514 NOCODAZOLE IC50 = 38.0 nM 7.42
CHEMBL149748 IC50 = 700.0 nM 6.16
CHEMBL155162 IC50 = 730.0 nM 6.14
CHEMBL149572 IC50 = 740.0 nM 6.13
CHEMBL151945 IC50 = 760.0 nM 6.12
CHEMBL155223 IC50 = 2000.0 nM 5.70
CHEMBL150758 IC50 = 2200.0 nM 5.66
CHEMBL433544 IC50 = 2800.0 nM 5.55
CHEMBL346848 IC50 = 5000.0 nM 5.30
CHEMBL153091 IC50 = 6900.0 nM 5.16
CHEMBL150902 IC50 = 7400.0 nM 5.13
CHEMBL358941 IC50 = 8200.0 nM 5.09
CHEMBL153699 IC50 = 8600.0 nM 5.07
CHEMBL153323 IC50 = 10000.0 nM 5.00
CHEMBL150659 IC50 = 10000.0 nM 5.00
CHEMBL153338 IC50 = 10000.0 nM 5.00
CHEMBL358937 IC50 > 10000.0 nM -