Assay Detail
Functional
CHEMBL707402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration for 50% inhibition of A-23187-stimulated radiolabeled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17344 | RITOLUKAST | 2.0 | 1 | 5.70 |
| CHEMBL79453 | — | — | 1 | 4.85 |
| CHEMBL162358 | TOMELUKAST | 2.0 | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17344 | RITOLUKAST | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL79453 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL162358 | TOMELUKAST | IC50 | = | 18900.0 | nM | 4.72 |