Assay Detail
Functional
CHEMBL707569
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Dose required to achieve 50% protection of MT-4 cells from HIV-1 induced cytopathogenicity
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 5.73 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.52 |
| CHEMBL109389 | — | — | 1 | 6.22 |
| CHEMBL33238 | — | — | 1 | 6.22 |
| CHEMBL284241 | — | — | 1 | 6.22 |
| CHEMBL112949 | — | — | 1 | 6.22 |
| CHEMBL109637 | — | — | 1 | 6.22 |
| CHEMBL112886 | — | — | 1 | 6.22 |
| CHEMBL322539 | — | — | 1 | 6.10 |
| CHEMBL114292 | — | — | 1 | 6.10 |
| CHEMBL32469 | — | — | 1 | 6.00 |
| CHEMBL109721 | — | — | 1 | 5.92 |
| CHEMBL111153 | — | — | 1 | 5.92 |
| CHEMBL110009 | — | — | 1 | 5.92 |
| CHEMBL109551 | — | — | 1 | 5.89 |
| CHEMBL111368 | — | — | 1 | 5.89 |
| CHEMBL110008 | — | — | 1 | 5.82 |
| CHEMBL111118 | — | — | 1 | 5.80 |
| CHEMBL114404 | — | — | 1 | 5.77 |
| CHEMBL110857 | — | — | 1 | 5.75 |
| CHEMBL110007 | — | — | 1 | 5.52 |
| CHEMBL111523 | — | — | 1 | 5.51 |
| CHEMBL320735 | — | — | 1 | 5.48 |
| CHEMBL419025 | — | — | 1 | 5.48 |
| CHEMBL111088 | — | — | 1 | 5.44 |
| CHEMBL325541 | — | — | 1 | 5.44 |
| CHEMBL108944 | — | — | 1 | 5.44 |
| CHEMBL109213 | — | — | 1 | 5.29 |
| CHEMBL111152 | — | — | 1 | 5.11 |
| CHEMBL109297 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL33238 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL284241 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL112949 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL109637 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL112886 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL109389 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL322539 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL114292 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL32469 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL111153 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL110009 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL109721 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL111368 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL109551 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL110008 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL111118 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL114404 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL110857 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL110007 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL111523 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL320735 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL419025 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL111088 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL325541 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL108944 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL109213 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL111152 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL109297 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL111181 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL107607 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL109538 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL109512 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL109772 | — | EC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL111200 | — | EC50 | > | 316000.0 | nM | - |
| CHEMBL323423 | — | EC50 | > | 406000.0 | nM | - |
| CHEMBL419928 | — | EC50 | > | 108000.0 | nM | - |
| CHEMBL112097 | — | EC50 | > | 165000.0 | nM | - |
| CHEMBL320303 | — | EC50 | > | 292000.0 | nM | - |
| CHEMBL111431 | — | EC50 | > | 5200.0 | nM | - |
| CHEMBL110476 | — | EC50 | > | 304000.0 | nM | - |
| CHEMBL321419 | — | EC50 | > | 69000.0 | nM | - |
| CHEMBL109807 | — | EC50 | > | 102000.0 | nM | - |
| CHEMBL109677 | — | EC50 | > | 25000.0 | nM | - |