Assay Detail

CHEMBL707652

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Functional

Antiproliferative effect against human lymphoma cells was determined; (0.012 to 0.12 nM)

ChEMBL ↗

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Target

Lymphoma cell line (CHEMBL614114) ↗

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Primary target Lymphoma cell line

CHEMBL614114

Anchored from Assay target.

Protein identity Lymphoma cell line

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Lymphoma cell line
Confidence	1 — Organism
Curated By	Intermediate

Target

Lymphoma cell line (CHEMBL614114) ↗

Type

CELL-LINE

Publication

Synthesis and in vitro cytotoxicity of diastereoisomerically modified dolastatin 15 analogues

Roux F, Galeotti N, Poncet J, Jouin P, Cros S, Zenke G
Bioorg Med Chem Lett (1994) 4 : 1947 -1950
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.92	10.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL35769	DOLASTATIN 15	—	1	10.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL35769	DOLASTATIN 15	IC50	=	0.012	nM	10.92