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Target Snapshot

CHEMBL614114 Target Snapshot

Lymphoma cell line · CELL-LINE

63Compounds
30Assays
2Approved Drugs
42.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lymphoma cell line as ChEMBL target CHEMBL614114. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lymphoma cell line
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL614114
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lymphoma cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLymphoma cell line
UniProt AccessionN/A

Lymphoma cell line

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lymphoma cell line.

Review nameLymphoma cell line
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5042.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL35769 10.92 IC50 0.012 Preclinical
CHEMBL4303060 7.96 IC50 11.0 Approved
CHEMBL25889 7.89 IC50 13.0 Preclinical
CHEMBL3353410 7.82 IC50 15.0 Approved
CHEMBL422395 6.25 IC50 560.0 Preclinical
CHEMBL5542372 5.8 IC50 1600.0 Preclinical
CHEMBL4573749 5.27 IC50 5360.0 Preclinical
CHEMBL4462590 5.26 IC50 5510.0 Preclinical
CHEMBL4592867 5.21 IC50 6090.0 Preclinical
CHEMBL4546151 4.99 IC50 10200.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
1
5.5
1
6.0
0
6.5
0
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MELPHALAN FLUFENAMIDE
CHEMBL4303060
Approved 2021
OSIMERTINIB
CHEMBL3353410
Approved 2015
Assay Landscape

Assay Landscape

30
Total Assays
19
Tested Compounds
2
Assay Types
Functional — 25 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 25 19 5.9
Toxicity — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine