Compound Detail
CHEMBL5542372
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Basic Information
| ChEMBL ID | CHEMBL5542372 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZKGRCIKQBHSNA-NFAWXSAZSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
333.7
MW (Da)
4.78
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lymphoma cell line CHEMBL614114 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Leukemia cell CHEMBL614844 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
| Eukaryotic initiation factor 4A-I CHEMBL2052028 | IC50 | 4.79 | 4.79 | 16400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lymphoma cell line | IC50 | = | 1600.0 | nM | 5.8 | Antitumor activity against human Lymphoma cell line assessed as inhibition of ce... | 37669595 |
| Leukemia cell | IC50 | = | 1700.0 | nM | 5.77 | Antitumor activity against human Leukemia cell assessed as inhibition of cell gr... | 37669595 |
| Eukaryotic initiation factor 4A-I | IC50 | = | 16400.0 | nM | 4.79 | Inhibition of EIF4A1 (unknown origin) assessed as ATP hydrolysis incubated for 1... | 37669595 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37669595 | 10.1016/j.ejmech.2023.115781 | Eukaryotic initiation factor 4A-I | 1 |
| 37669595 | 10.1016/j.ejmech.2023.115781 | Leukemia cell | 1 |
| 37669595 | 10.1016/j.ejmech.2023.115781 | Lymphoma cell line | 1 |
Data from ChEMBL 36 via Core Engine