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Target Snapshot

CHEMBL614844 Target Snapshot

Leukemia cell · CELL-LINE · Homo sapiens

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125Compounds
49Assays
1Approved Drugs
9.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leukemia cell as ChEMBL target CHEMBL614844. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leukemia cell
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614844
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leukemia cell still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeukemia cell
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeukemia cell
UniProt AccessionN/A

Leukemia cell

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leukemia cell.

Review nameLeukemia cell
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC508.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3781751 10.0 EC50 0.1 Clinical
CHEMBL4517151 7.67 IC50 21.2 Preclinical
CHEMBL5273139 7.0 IC50 100.0 Preclinical
CHEMBL5542372 5.77 IC50 1700.0 Preclinical
CHEMBL361497 5.16 IC50 6887.0 Approved
CHEMBL1096927 4.85 IC50 14000.0 Clinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
0
6.0
0
6.5
1
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

49
Total Assays
6
Tested Compounds
1
Assay Types
Functional — 49 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 46 6 6.7
mitochondrion format 2 0 —
organism-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine