Assay Detail
Functional
CHEMBL707814
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Concentration required for the inhibition of HIV replication by 50% in MT-4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and HIV activity of phosphonate isosteres of D4T monophosphate
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.91 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.92 |
| CHEMBL122885 | — | — | 1 | 5.89 |
| CHEMBL123340 | — | — | 1 | - |
| CHEMBL121760 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL122885 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL123340 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL121760 | — | IC50 | > | 1000000.0 | nM | - |