Assay Detail
Functional
CHEMBL708018
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Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.47 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537929 | — | — | 1 | 8.67 |
| CHEMBL556031 | — | — | 1 | 8.46 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.42 |
| CHEMBL89705 | TALLIMUSTINE | 2.0 | 1 | 7.26 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 7.05 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537929 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL556031 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 37.84 | nM | 7.42 |
| CHEMBL89705 | TALLIMUSTINE | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 89.91 | nM | 7.05 |
| CHEMBL852 | MELPHALAN | IC50 | = | 1097.64 | nM | 5.96 |