Assay Detail
Functional
CHEMBL708019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537929 | — | — | 1 | 9.19 |
| CHEMBL556031 | — | — | 1 | 8.98 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.40 |
| CHEMBL89705 | TALLIMUSTINE | 2.0 | 1 | 7.31 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.74 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537929 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL556031 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 39.56 | nM | 7.40 |
| CHEMBL89705 | TALLIMUSTINE | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 183.15 | nM | 6.74 |
| CHEMBL852 | MELPHALAN | IC50 | = | 5393.18 | nM | 5.27 |