Assay Detail
Functional
CHEMBL708077
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Inhibitory activity in mice bearing L1210 leukemia
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.02 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10611 | — | — | 1 | 8.12 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.05 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 7.92 |
| CHEMBL267815 | — | — | 1 | 7.92 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 7.75 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.64 |
| CHEMBL273685 | — | — | 1 | 7.54 |
| CHEMBL275019 | — | — | 1 | 7.36 |
| CHEMBL10376 | — | — | 1 | 7.32 |
| CHEMBL263974 | — | — | 1 | 7.31 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.25 |
| CHEMBL276477 | — | — | 1 | 7.25 |
| CHEMBL10510 | — | — | 1 | 7.21 |
| CHEMBL10391 | — | — | 1 | 7.19 |
| CHEMBL10741 | — | — | 1 | 7.16 |
| CHEMBL10250 | — | — | 1 | 7.16 |
| CHEMBL275542 | — | — | 1 | 7.14 |
| CHEMBL10724 | — | — | 1 | 7.10 |
| CHEMBL267814 | — | — | 1 | 7.05 |
| CHEMBL273949 | — | — | 1 | 6.89 |
| CHEMBL10960 | — | — | 1 | 6.82 |
| CHEMBL10571 | — | — | 1 | 6.75 |
| CHEMBL430136 | — | — | 1 | 6.60 |
| CHEMBL10364 | — | — | 1 | 6.58 |
| CHEMBL428675 | — | — | 1 | 6.57 |
| CHEMBL10613 | — | — | 1 | 6.44 |
| CHEMBL273635 | — | — | 1 | 6.43 |
| CHEMBL10419 | — | — | 1 | 6.40 |
| CHEMBL274382 | — | — | 1 | 6.16 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10611 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL267815 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL273685 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL275019 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL10376 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL263974 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL276477 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL10510 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL10391 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL10741 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL10250 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL275542 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL10724 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL267814 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL273949 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL10960 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL10571 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL430136 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL10364 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL428675 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL10613 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL273635 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL10419 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL274382 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1159709 | — | IC50 | = | 26000.0 | nM | 4.58 |