Assay Detail
Functional
CHEMBL708078
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In vitro inhibitory activity against murine L1210 leukemia
34
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.24 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338604 | C-1311 | 2.0 | 2 | 7.51 |
| CHEMBL124734 | — | — | 2 | 7.47 |
| CHEMBL124374 | — | — | 2 | 7.32 |
| CHEMBL124373 | — | — | 2 | 6.87 |
| CHEMBL123853 | — | — | 2 | 6.75 |
| CHEMBL124792 | — | — | 2 | 6.64 |
| CHEMBL125082 | — | — | 2 | 6.60 |
| CHEMBL340884 | — | — | 2 | 6.11 |
| CHEMBL334101 | — | — | 2 | 6.05 |
| CHEMBL125107 | — | — | 2 | 5.85 |
| CHEMBL124254 | — | — | 2 | 5.81 |
| CHEMBL125750 | — | — | 2 | 5.78 |
| CHEMBL124629 | — | — | 2 | 5.75 |
| CHEMBL123632 | — | — | 2 | 5.60 |
| CHEMBL123677 | — | — | 2 | 5.50 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 2 | 5.44 |
| CHEMBL124627 | — | — | 2 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338604 | C-1311 | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL124734 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL124374 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL124373 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL123853 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL124792 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL125082 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL340884 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL334101 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL125107 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL124254 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL125750 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL124629 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL123632 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL123677 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL124627 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL334101 | — | IC50 | = | 0.4 | ug.mL-1 | - |
| CHEMBL123632 | — | IC50 | = | 1.1 | ug.mL-1 | - |
| CHEMBL125107 | — | IC50 | = | 0.7 | ug.mL-1 | - |
| CHEMBL123677 | — | IC50 | = | 1.4 | ug.mL-1 | - |
| CHEMBL125082 | — | IC50 | = | 0.11 | ug.mL-1 | - |
| CHEMBL124373 | — | IC50 | = | 0.06 | ug.mL-1 | - |
| CHEMBL124629 | — | IC50 | = | 0.78 | ug.mL-1 | - |
| CHEMBL124627 | — | IC50 | = | 3.5 | ug.mL-1 | - |
| CHEMBL124374 | — | IC50 | = | 0.02 | ug.mL-1 | - |
| CHEMBL123853 | — | IC50 | = | 0.08 | ug.mL-1 | - |
| CHEMBL124734 | — | IC50 | = | 0.014 | ug.mL-1 | - |
| CHEMBL124792 | — | IC50 | = | 0.1 | ug.mL-1 | - |
| CHEMBL124254 | — | IC50 | = | 0.7 | ug.mL-1 | - |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 1.77 | ug.mL-1 | - |
| CHEMBL338604 | C-1311 | IC50 | = | 0.013 | ug.mL-1 | - |
| CHEMBL125750 | — | IC50 | = | 0.65 | ug.mL-1 | - |
| CHEMBL340884 | — | IC50 | = | 0.34 | ug.mL-1 | - |