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Assay Detail

CHEMBL708140

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of the collagenase enzyme.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent and selective inhibitors of gelatinase-a 1. hydroxamic acid derivatives
Porter JR, Beeley NR, Boyce BA, Mason B, Millican A, Millar K, Leonard J, Morphy J, O'Connell JP
Bioorg Med Chem Lett (1994) 4 : 2741 -2746
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 6.30 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL77754 1 8.11
CHEMBL92828 1 6.87
CHEMBL93395 1 6.71
CHEMBL75403 1 6.69
CHEMBL308511 1 6.53
CHEMBL91655 1 6.52
CHEMBL93890 1 6.52
CHEMBL93695 1 6.50
CHEMBL93791 1 6.50
CHEMBL93235 1 6.50
CHEMBL92453 1 6.48
CHEMBL93583 1 6.42
CHEMBL92600 1 6.42
CHEMBL328092 1 6.34
CHEMBL77808 1 6.21
CHEMBL94114 1 6.19
CHEMBL312076 1 6.04
CHEMBL90743 1 6.03
CHEMBL327472 1 5.98
CHEMBL310037 1 5.82
CHEMBL311397 1 5.61
CHEMBL73803 1 5.60
CHEMBL76519 1 5.30
CHEMBL415074 1 5.29
CHEMBL327780 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL77754 Ki = 7.8 nM 8.11
CHEMBL92828 Ki = 135.0 nM 6.87
CHEMBL93395 Ki = 193.0 nM 6.71
CHEMBL75403 Ki = 203.0 nM 6.69
CHEMBL308511 Ki = 296.0 nM 6.53
CHEMBL91655 Ki = 302.0 nM 6.52
CHEMBL93890 Ki = 303.0 nM 6.52
CHEMBL93695 Ki = 313.0 nM 6.50
CHEMBL93791 Ki = 313.0 nM 6.50
CHEMBL93235 Ki = 319.0 nM 6.50
CHEMBL92453 Ki = 329.0 nM 6.48
CHEMBL93583 Ki = 385.0 nM 6.42
CHEMBL92600 Ki = 382.0 nM 6.42
CHEMBL328092 Ki = 455.0 nM 6.34
CHEMBL77808 Ki = 618.0 nM 6.21
CHEMBL94114 Ki = 642.0 nM 6.19
CHEMBL312076 Ki = 921.0 nM 6.04
CHEMBL90743 Ki = 942.0 nM 6.03
CHEMBL327472 Ki = 1050.0 nM 5.98
CHEMBL310037 Ki = 1530.0 nM 5.82
CHEMBL311397 Ki = 2440.0 nM 5.61
CHEMBL73803 Ki = 2500.0 nM 5.60
CHEMBL76519 Ki = 5000.0 nM 5.30
CHEMBL415074 Ki = 5120.0 nM 5.29
CHEMBL327780 Ki > 10000.0 nM -