Assay Detail
Binding
CHEMBL708141
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Inhibition of the Collagenase enzyme was determined from purified NSO cells.
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NSO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 4.54 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75403 | — | — | 1 | 6.69 |
| CHEMBL309067 | — | — | 1 | 5.00 |
| CHEMBL76869 | — | — | 2 | 4.77 |
| CHEMBL91055 | — | — | 1 | 4.70 |
| CHEMBL77461 | — | — | 1 | 4.68 |
| CHEMBL307365 | — | — | 1 | 4.66 |
| CHEMBL307211 | — | — | 1 | 4.66 |
| CHEMBL74977 | — | — | 1 | 4.60 |
| CHEMBL77956 | — | — | 1 | 4.55 |
| CHEMBL432346 | — | — | 1 | 4.40 |
| CHEMBL75148 | — | — | 1 | 4.38 |
| CHEMBL78335 | — | — | 1 | 4.32 |
| CHEMBL420376 | — | — | 1 | 4.26 |
| CHEMBL307027 | — | — | 1 | 4.26 |
| CHEMBL78047 | — | — | 1 | 4.24 |
| CHEMBL306177 | — | — | 1 | 4.00 |
| CHEMBL307207 | — | — | 1 | 4.00 |
| CHEMBL306779 | — | — | 1 | 4.00 |
| CHEMBL91054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75403 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL309067 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL76869 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL91055 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL77461 | — | Ki | = | 21100.0 | nM | 4.68 |
| CHEMBL307365 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL307211 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL74977 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL77956 | — | Ki | = | 28400.0 | nM | 4.55 |
| CHEMBL432346 | — | Ki | = | 40200.0 | nM | 4.40 |
| CHEMBL75148 | — | Ki | = | 41400.0 | nM | 4.38 |
| CHEMBL78335 | — | Ki | = | 47800.0 | nM | 4.32 |
| CHEMBL420376 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL307027 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL78047 | — | Ki | = | 57800.0 | nM | 4.24 |
| CHEMBL306177 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL307207 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL306779 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL76869 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL91054 | — | Ki | > | 10000.0 | nM | - |