Assay Detail
Binding
CHEMBL708143
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Inhibition of human fibroblast collagenase, matrix metalloprotease-1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hydroxamate inhibitors of human gelatinase B (92 kDa)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.70 |
| CHEMBL11306 | — | — | 1 | 8.22 |
| CHEMBL410259 | — | — | 1 | 8.10 |
| CHEMBL59023 | — | — | 1 | 7.58 |
| CHEMBL324369 | — | — | 1 | 6.75 |
| CHEMBL117720 | — | — | 1 | 6.52 |
| CHEMBL325015 | — | — | 1 | 5.85 |
| CHEMBL87229 | — | — | 1 | 5.82 |
| CHEMBL419301 | — | — | 1 | 5.72 |
| CHEMBL116318 | — | — | 1 | 5.08 |
| CHEMBL332891 | — | — | 1 | 5.07 |
| CHEMBL117296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL11306 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL410259 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL59023 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL324369 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL117720 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL325015 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL87229 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL419301 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL116318 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL332891 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL117296 | — | Ki | > | 100.0 | nM | - |