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Assay Detail

CHEMBL708144

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of matrix metalloprotease-1 (MMP-1)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Orally active inhibitors of stromelysin-1 (MMP-3)
Chapman KT, Durette PL, Caldwell CG, Sperow KM, Niedzwiecki LM, Harrison RK, Saphos C, Christen AJ, Olszewski JM, Moore VL, MacCoss M, Hagmann WK
Bioorg Med Chem Lett (1996) 6 : 803 -806
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 5.72 6.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL112180 1 6.14
CHEMBL8494 L-696418 1 6.11
CHEMBL267536 1 5.80
CHEMBL167705 1 5.33
CHEMBL8474 1 5.23
CHEMBL349397 1 -
CHEMBL352609 1 -
CHEMBL168150 1 -
CHEMBL167302 1 -
CHEMBL8256 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL112180 Ki = 720.0 nM 6.14
CHEMBL8494 L-696418 Ki = 770.0 nM 6.11
CHEMBL267536 Ki = 1600.0 nM 5.80
CHEMBL167705 Ki = 4620.0 nM 5.33
CHEMBL8474 Ki = 5900.0 nM 5.23
CHEMBL349397 Ki > 10000.0 nM -
CHEMBL352609 Ki > 10000.0 nM -
CHEMBL168150 Ki > 10000.0 nM -
CHEMBL167302 Ki > 10000.0 nM -
CHEMBL8256 Ki > 10000.0 nM -