Assay Detail
Binding
CHEMBL708145
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Inhibition of human fibroblast collagenase, matrix metalloprotease-1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel indolactam-based inhibitors of matrix metalloproteinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.10 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281795 | — | — | 1 | 10.00 |
| CHEMBL30980 | — | — | 1 | 9.00 |
| CHEMBL285112 | — | — | 1 | 8.64 |
| CHEMBL285418 | — | — | 1 | 8.52 |
| CHEMBL30804 | — | — | 1 | 8.30 |
| CHEMBL30782 | — | — | 1 | 7.70 |
| CHEMBL282146 | — | — | 1 | 7.60 |
| CHEMBL286904 | — | — | 1 | 6.77 |
| CHEMBL31164 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281795 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL30980 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL285112 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL285418 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL30804 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL30782 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL282146 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL286904 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL31164 | — | Ki | = | 432.0 | nM | 6.37 |